Donor Lymphocyte Infusion of Non-Cryopreserved Stem Cell Boost

(2Q 2025 Coding Clinic)

A patient who is status post allogeneic stem cell transplant was diagnosed with failed remission of acute lymphoid leukemia. The patient was admitted and underwent donor lymphocyte infusion of non-cryopreserved (allogeneic/ haploidentical/syngeneic) cells via a central venous catheter (CVC), documented as a “stem cell boost.” Assign code 30243Q1, Transfusion of nonautologous white cells into central vein, percutaneous approach, for the stem cell boost, when administered through a central vein. Donor lymphocyte infusion involves transfusing healthy white blood cells from the original stem cell donor, to give the patient a therapeutic stem cell boost.

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